EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

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Israelis, Palestinians lob threats via Twitter

RT @ElizabethCNN: Tamils want inquiry after UN says it 'failed civilians' in bloody Sri Lanka civil war - http://t.co/Pd6AAWBT http://t ...

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Afghan officials: Pakistan frees Taliban detainees

KABUL, Afghanistan (AP) — Pakistan has freed eight Taliban prisoners and has agreed to release many more to help kick start a peace process that could lead to a political resolution of the 11-year-old Afghan war, Afghan officials said Thursday.

The decision to release the prisoners, including the former justice minister from when the repressive Taliban ruled Afghanistan, is seen as a signal that neighboring Pakistan might be willing to take concrete steps to revive efforts to lure the group to the negotiating table.

The three Afghan officials, who spoke on condition of anonymity as they are not yet authorized to discuss the results of the sensitive meetings in Islamabad, are familiar with the four-day trip that the Afghan government's peace council made there this week.

The U.S. and its allies fighting in Afghanistan are pushing to strike a peace deal with the Taliban so they can withdraw most of their troops by the end of 2014. But considerable obstacles remain, and it is unclear whether the Taliban even intend to take part in the process, rather than just wait until foreign forces withdraw.

Pakistan is seen as key to the peace process. Islamabad has ties to the Taliban that date back to the 1990s, and many of the group's leaders are believed to be based on Pakistani territory, having fled there following the U.S.-led invasion of Afghanistan in 2001.

The officials said the first group of prisoners was released on Wednesday as a goodwill gesture, and that Pakistani officials had agreed to free anywhere from 15 to 32 more prisoners in the future to help build traction for formal talks with the Taliban.

Two of the officials said former Taliban Justice Minister Nooruddin Turabi was among those released on Wednesday. Turabi, a native of Kandahar who is in his late 40s or early 50s, is missing an eye and has only one leg. He is believed to have played a role in the destruction of two, 1,500-year-old sandstone Buddha statues that once towered some 180 feet high in central Afghanistan. The Taliban, who considered them symbols of paganism, destroyed them in 2001.

A joint statement issued by Pakistan and Afghanistan on Wednesday said "a number of Taliban detainees are being released" to support the peace process at the request of the Afghan government. It also called on the Taliban and other armed opposition groups to participate in peace talks and sever links with al-Qaida. Neither the Pakistani nor Afghan governments have officially confirmed the identities of the prisoners released.

However, one of the officials familiar with the peace process gave The Associated Press a list of the Taliban prisoners — some identified by only one name — that Pakistan agreed to release. The eight prisoners on the list were:

—Turabi.

—Jahangirwal, who was a special assistant for the Taliban's top leader, Mullah Omar.

—Qutub, a Taliban leader.

—Abdul Salaam, the Taliban's former governor of Baghlan province.

—Maulvi Matiullah, who was director of the customs house in Kabul under the Taliban regime;

—Mahamad, the Taliban's former governor of Kunduz province.

—Sayed Saduddin Agha, a former Taliban commander.

—Allah Dad, the Taliban's former deputy minister of communication.

The eight are among 40 Taliban prisoners that the Afghan government has asked Pakistan to release.

Also on the list of 40 is the Taliban's former deputy leader, Mullah Abdul Ghani Baradar, who was captured in Pakistan in 2010.

Baradar is seen by some as crucial to the peace process. Baradar was reportedly conducting talks with the Afghan government that were kept secret from the Pakistanis, and his arrest in the sprawling southern port city of Karachi reportedly angered Afghan President Hamid Karzai.

Pakistan helped the Taliban seize control of Afghanistan in the 1990s — providing funding, weapons and intelligence — and the Afghan government and the U.S. have accused Islamabad of continuing to support the group. Pakistan has denied the allegations, but many analysts believe the country continues to see the militant group as an important ally in Afghanistan to counter archenemy India.

However, Pakistan is also worried about instability in Afghanistan following the planned withdrawal of foreign forces. If civil war breaks out again as it did in the 1990s, hundreds of thousands of Afghan refugees could stream across the border into Pakistan. Violence could also give greater cover to Pakistani militants who are at war with Islamabad.

These concerns have made a peace deal more urgent in the minds of Pakistanis.

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Associated Press writers Kathy Gannon in Islamabad, Pakistan, and Deb Riechmann in Kabul contributed to this report.

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DA: Heroin charge dropped vs. Bon Jovi's daughter

CLINTON, N.Y. (AP) — Drug charges against Jon Bon Jovi's 19-year-old daughter have been dropped, a central New York prosecutor said Thursday.

Stephanie Bongiovi was found unresponsive by medics after she apparently overdosed on heroin in a Hamilton College dorm early Wednesday. Town of Kirkland police charged Bongiovi, of Red Bank, N.J., and fellow student Ian Grant, also of Red Bank, with possession of a small amount of heroin and marijuana.

Oneida County District Attorney Scott McNamara said he was dismissing the charges against both students. Under state law, someone having a drug overdose or seeking help for an overdose victim can't be prosecuted for having a small amount of heroin or any amount of marijuana.

The so-called Good Samaritan 911 law signed by Gov. Andrew Cuomo in July 2011 was designed to reduce overdose deaths by encouraging people to call 911 without fear of being arrested for drug possession. Similar laws have been passed in several other states.

Bon Jovi, 50, is scheduled to perform at a concert to benefit Hamilton's scholarships and arts programs in Times Square on Dec. 5. He has not commented on his daughter's overdose.

He has four children, Stephanie and three sons.

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Diabetes rates rocket in Oklahoma, South

NEW YORK (AP) — The nation's diabetes problem is getting worse, and the biggest jump over 15 years was in Oklahoma, according to a new federal report issued Thursday.

The diabetes rate in Oklahoma more than tripled, and Kentucky, Georgia and Alabama also saw dramatic increases since 1995, the study showed.

The South's growing weight problem is the main explanation, said Linda Geiss, lead author of the report by the Centers for Disease Control and Prevention study.

"The rise in diabetes has really gone hand in hand with the rise in obesity," she said.

Bolstering the numbers is the fact that more people with diabetes are living longer because better treatments are available.

The disease exploded in the United States in the last 50 years, with the vast majority from obesity-related Type 2 diabetes. In 1958, fewer than 1 in 100 Americans had been diagnosed with diabetes. In 2010, it was about 1 in 14.

Most of the increase has happened since 1990.

Diabetes is a disease in which the body has trouble processing sugar; it's the nation's seventh leading cause of death. Complications include poor circulation, heart and kidney problems and nerve damage.

The new study is the CDC's first in more than a decade to look at how the nationwide boom has played out in different states.

It's based on telephone surveys of at least 1,000 adults in each state in 1995 and 2010. Participants were asked if a doctor had ever told them they have diabetes.

Not surprisingly, Mississippi — the state with the largest proportion of residents who are obese — has the highest diabetes rate. Nearly 12 percent of Mississippians say they have diabetes, compared to the national average of 7 percent.

But the most dramatic increases in diabetes occurred largely elsewhere in the South and in the Southwest, where rates tripled or more than doubled. Oklahoma's rate rose to about 10 percent, Kentucky went to more than 9 percent, Georgia to 10 percent and Alabama surpassed 11 percent.

An official with Oklahoma State Department of Health said the solution is healthier eating, more exercise and no smoking.

"And that's it in a nutshell," said Rita Reeves, diabetes prevention coordinator.

Several Northern states saw rates more than double, too, including Washington, Idaho, Montana, Wyoming, South Dakota, Minnesota, Missouri, Ohio and Maine.

The study was published in CDC's Morbidity and Mortality Weekly Report.

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Associated Press writer Ken Miller in Oklahoma City contributed to this report.

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Online:

CDC report: http://tinyurl.com/cdcdiabetesreport

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U.S. backs Israeli response to Gaza attacks

Israeli soldiers ride on top of an armored personnel carrier close to the Israel-Gaza border, in southern Israel. …The White House on Thursday threw its full support behind Israel's military response to a barrage of rockets fired by the Islamist Palestinian movement Hamas that rules the Gaza Strip. Deputy National Security Adviser for Strategic Communications Ben Rhodes said it would be "up to the Israeli government" whether to follow up punishing airstrikes with a ground assault.

"Our view is that the Israelis have the right of self-defense when their citizens are faced with the threat of indiscriminate rocket fire from within Gaza," Rhodes told reporters on a conference call.

Asked whether the Obama administration would have any issues with an Israeli ground assault, Rhodes replied that "ultimately, it's up to the Israeli government to make determinations about how they're going to carry out their military objectives."

The Associated Press has reported that Hamas fired more than 200 rockets on Thursday, killing three people, and that Israel seemed to be gearing up for a ground invasion of Gaza. The escalating conflict amounted to President Barack Obama's first major foreign policy test since winning re-election Nov. 6. Rhodes said American officials were in close consultation with their Israeli counterparts "to have an understanding of their plans going forward." The Obama administration has been in discussions with Turkey, Egypt and "some of our European partners," he said, thought to have sway over Hamas in order to get them to urge the militant organization to halt its rocket attacks.

"At the United Nations, where this is being discussed, we've sought to keep the focus where it should be—which is on Hamas's rocket fire as the precipitating cause here," Rhodes explained.

"What we've also said is that the best course of action would be for there to be a general de-escalation of the violence, but that the onus is on Hamas—and those with influence over Hamas—to help bring about that de-escalation, so that we don't see a widening conflict," he told reporters. "So we certainly want to see a de-escalation, we certainly want to see a broader conflict avoided."

The official noted that the White House has urged Israel to take "all steps ... to avoid civilian casualties." He added, "And we deeply regret the loss of life on the Israeli and Palestinian side."

Israeli Ambassador to the United States Michael Oren briefed key senators on the operation. The lawmakers—Democrats and Republicans—released a joint statement expressing "solidarity" with Israel while warning that "escalation will only lead to further suffering on both sides."

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Report: Sri Lankan war was grave failure for UN

UNITED NATIONS (AP) — A United Nations report released Wednesday said inadequate efforts by the world body to protect civilians during the bloody final months of Sri Lanka's civil war marked a "grave failure" that led to suffering for hundreds of thousands of people.

The report was unusually scathing for an official U.N. critique.

The report accused U.N. staff in Colombo of not perceiving that preventing civilian deaths was their responsibility and accused their bosses at U.N. headquarters of not telling them otherwise. A separate U.N. report released last year said up to 40,000 ethnic minority Tamil civilians may have been killed in the war's final months.

"This report is a benchmark moment for the U.N. in the same way that Rwanda was," said Gordon Weiss, a former U.N. spokesman in Sri Lanka.

The report accused U.N. officials and member states of being reluctant to interfere and leaving the conflict in a "vacuum of inaction."

"The report concludes that the United Nations system failed to meet its responsibilities — highlighting, in particular, the roles played by the Secretariat, the agencies and programs of the U.N. Country Team and the members of the Security Council and Human Rights Council," Secretary-General Ban Ki-moon said in a statement.

The report was compiled by a committee headed by former U.N. official Charles Petrie. It investigated U.N. actions as the quarter-century war between the government, dominated by the ethnic Sinhalese majority, and minority Tamil rebels ended in 2009 in a wave of violence.

The BBC first reported on a draft of the report Tuesday.

The draft, obtained by The Associated Press shortly before the final report was released, began with an "executive summary" that detailed the U.N. failure on the ground, saying that the political conditions after the Sept. 11, 2001, terror attacks in the U.S. made countries less likely to stop a government fighting against a group — the Tamil Tiger rebels — that many had branded a terrorist organization.

The executive summary was deleted from the official published version issued on Wednesday.

The draft report painted a picture of a U.N. operation reluctant to criticize the government or accuse it of killing civilians with artillery bombardments, out of concern the government would respond by limiting U.N. humanitarian access — even through U.N. aid workers were barred from the northern war zone in late 2008.

Top U.N. officials in the country repeatedly worked to soften statements to remove casualty figures and accusations of possible war crimes against the government, the official report said. When death tolls its staff was compiling were released, top officials dismissed them as unverified despite the rigorous methodology being used, the report said.

When U.N. satellite images confirmed heavy artillery shelling in the war zone and showed far more civilians there than the government claimed, the top U.N. official in Sri Lanka downplayed the evidence in a letter to the government, the final version of the report said. At the same time, member states did not hold a single formal meeting on the conflict in its final months in the Security Council, Human Rights Council or the General Assembly.

"The UN set itself up for failure, in Sri Lanka," the draft report said, in another quote deleted from the final, official report.

The report also accused the government of working to intimidate U.N. staff, of withholding visas of those critical of the government and of planting false allegations against them in the media.

The U.N. representative for Human Rights Watch, Philippe Bolopion, said "The U.N.'s dereliction of duty in Sri Lanka is a stark reminder of what happens when human rights concerns are marginalized or labeled as too political."

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Nessman reported from New Delhi.

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NBC names new top producer for 'Today'

NEW YORK (AP) — NBC News is staying in-house in its effort to turn around the "Today" show.

The network on Wednesday appointed a 23-year veteran of the morning news show as its new executive producer. Don Nash began working for "Today" as a production assistant in NBC's Burbank office in 1989 and will now run the four-hour broadcast.

Nash was most recently senior broadcast producer in the show's control room. He replaces Jim Bell, who shifted to NBC Sports to run its Olympics broadcasts.

After nearly two decades of dominance, "Today" has slipped behind ABC's "Good Morning America" in the ratings.

NBC also added another layer of management for the show, appointing Alexandra Wallace as the network's executive in charge of the program.

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New gene triples risk for Alzheimer's disease

Scientists have identified a new gene variant that seems to strongly raise the risk for Alzheimer's disease, giving a fresh target for research into treatments for the mind-robbing disorder.

The problem gene is not common — less than 1 percent of people are thought to have it — but it roughly triples the chances of developing Alzheimer's compared to people with the normal version of the gene. It also seems to harm memory and thinking in older people without dementia.

The main reason scientists are excited by the discovery is what this gene does, and how that might reveal what causes Alzheimer's and ways to prevent it. The gene helps the immune system control inflammation in the brain and clear junk such as the sticky deposits that are the hallmark of the disease. Mutations in the gene may impair these tasks, so treatments to restore the gene's function and quell inflammation may help.

"It points us to potential therapeutics in a more precise way than we've seen in the past," said Dr. William Thies, chief medical and scientific officer of the Alzheimer's Association, which had no role in the research. Years down the road, this discovery will likely be seen as very important, he predicted.

It is described in a study by an international group published online Wednesday by the New England Journal of Medicine.

About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.

Until now, only one gene — ApoE — has been found to have a big impact on Alzheimer's risk. About 17 percent of the population has at least one copy of the problem version of this gene but nearly half of all people with Alzheimer's do. Other genes that have been tied to the disease raise risk only a little, or cause the less common type of Alzheimer's that develops earlier in life, before age 60.

The new gene, TREM2, already has been tied to a couple other forms of dementia. Researchers led by deCODE Genetics Inc. of Iceland honed in on a version of it they identified through mapping the entire genetic code of more than 2,200 Icelanders.

Further tests on 3,550 Alzheimer's patients and more than 110,000 people without dementia in several countries, including the United States, found that the gene variant was more common in Alzheimer's patients.

"It's a very strong effect," raising the risk of Alzheimer's by three to four times — about the same amount as the problem version of the ApoE gene does, said Dr. Allan Levey, director of an Alzheimer's program at Emory University, one of the academic centers participating in the research.

Researchers also tested more than 1,200 people over age 85 who did not have Alzheimer's disease and found that those with the variant TREM2 gene had lower mental function scores than those without it. This adds evidence the gene variant is important in cognition, even short of causing Alzheimer's.

"It's another piece in the puzzle. It suggests the immune system is important in Alzheimer's disease," said Andrew Singleton, a geneticist with the National Institute on Aging, which helped pay for the study.

One prominent scientist not involved in the study — Dr. Rudolph Tanzi, a Harvard Medical School geneticist and director of an Alzheimer's research program at Massachusetts General Hospital — called the work exciting, but added a caveat.

"I would like to see more evidence that this is Alzheimer's" rather than one of the other dementias already tied to the gene, Tanzi said. Autopsy or brain imaging tests can show whether the cases attributed to the gene variant are truly Alzheimer's or misdiagnosed, he said.

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Online:

Medical journal: http://www.nejm.org

Alzheimer's info: http://www.alzheimers.gov

Alzheimer's Association: http://www.alz.org

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Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

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Clinton-Lewinsky 'spinners' resurface

WASHINGTON (Reuters) - It's a case of déjà vu in D.C.: some of the same high-profile, high-priced handlers who played supporting roles in the scandal over President Bill Clinton's affair with intern Monica Lewinsky have re-emerged in the sex scandal that has toppled one U.S. national security chief and threatens another.

It is unclear what will be the roles of the expensive legal and crisis-management talent drawn into the uproar over the relationships between former CIA director David Petraeus and Marine General John Allen and two female acquaintances. Neither Republicans nor Democrats in Congress appear to have an appetite for another year-long Monica-style media spectacle.

The latest scandal began with an FBI investigation into cyber-harassment, and indications so far are that ultimately the inquiry will produce no criminal charges.

Nonetheless, both women at the center of attention - Petraeus biographer and former mistress Paula Broadwell and Tampa socialite Jill Kelley, the woman to whom Broadwell is alleged to have sent suspected harassing emails - have turned for advice to veteran Washington lawyers and spin doctors with connections to the Lewinsky brouhaha.

On Monday, a source close to the Kelley family said that two Washington-based players in the Lewinsky scandal, trial lawyer Abbe Lowell and public relations adviser Judy Smith, were working for Kelley.

A day later, a Washington law firm which represented Lewinsky herself confirmed that one of its partners, Robert F. Muse, was representing Broadwell. The three advisors either were unavailable for comment or declined to comment.

It is not known whether Petraeus or Allen, who is the top U.S. military commander in Afghanistan, have retained attorneys.

 

A complaint by Kelley to the FBI about the harassing emails sparked an investigation that implicated Petraeus in a career-ending affair with Broadwell.

It also embroiled Kelley herself in the uproar over her still-murky relationship with Allen.

Kelley's lawyer, Lowell, who an insider said she had known for years, served as pro-Clinton Democratic Party chief counsel on a House impeachment inquiry. Recently he won a partial acquittal and partial mistrial for John Edwards, a former Democratic U.S. senator and vice presidential candidate who had been indicted for misusing undeclared campaign funds to support his mistress.

During the Clinton sex scandal, Smith, a one-time press aide to President George H.W. Bush, served as Lewinsky's spokeswoman. Smith also represented NFL quarterback Michael Vick, who was charged and convicted in a dogfighting cruelty case.

Smith also is a model for the main character in the ABC-TV drama "Scandal," a prime-time series in which ace spin-doctor Olivia Pope, along with a team of spies and ex-convicts, not only manages to sort out or cover up sex and spy scandals but also carries on a secret affair with a fictional U.S. president.

Muse's senior partner, Jacob Stein, and another prominent criminal lawyer from a different firm, Plato Cacheris, represented Lewinsky personally in a criminal investigation of Clinton by special prosecutor Kenneth Starr and a congressional inquiry which led to Clinton's impeachment by the House of Representatives but subsequent acquittal by the Senate. Muse himself did not represent Lewinsky, according to Cacheris.

Starr and a substantial special prosecution team pursued Clinton during the Lewinsky scandal. Starr turned his evidence over to the Republican-controlled House, which in a nationally televised broadcast impeached Clinton for high crimes and misdemeanors.

But Republicans could not muster the two-thirds majority in the Senate needed to remove Clinton from office. Republicans later were punished at the polls for what many of them conceded was a perceived overzealousness in pursuing Clinton.

CONGRESS WARY OF SPECTACLE

Lewinsky's lawyers were critical in helping her negotiate a legal thicket that included dealing with Starr's criminal investigators and the impeachment inquiry launched by Congress; she testified in both investigations. Lewinsky was also besieged for months by the media; eventually her team arranged decorous interviews with U.S. and British television networks.

Mindful of how the Lewinsky scandal played out, officials familiar with the views of both senior Democrats and Republicans in Congress say that congressional leaders are keen to avoid turning the scandal into a public extravaganza, even though there remain many unanswered questions.

If there are no public congressional hearings or a criminal prosecution, it is unclear what Broadwell's and Kelley's legal and public relations teams would do, apart from trying to manage news coverage and the hordes of paparazzi and TV cameramen now outside their clients' homes.

Lewinsky's lawyer, Cacheris, told Reuters that from what he could see, at this point Broadwell and Kelley do not know if there will be any charges against them. "These people are getting lawyers to ensure there is no criminal case," he added.

But Eric Dezenhall, a Washington crisis management expert, said some clients did not understand that there was a limit to how much even the most skilled lawyer and public relations specialist could do.

"You have to be very selective in the cases you take because you're going to end up with some very disgruntled clients," Dezenhall said.

(Editing by Warren Strobel and Paul Simao)

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